Compare and contrast the tradional marker and new marker of liver Essay

Compare and contrast the tradional marker and new marker of liver fibrosis - Essay Example But is is fraught with several disadvantages and recent novel methods claim to overcome the disadvantages associated with liver biopsy. In this research article, both traditional and novel methods of liver biopsy evaluation are discussed. Novel assessment strategies include serological assays, imaging methods and genetic studies. There are 2 types of biochemical markers and they are direct and indirect. Direct markers evaluate for fibrolysis and fibrogenesis. There is evidence to show that there does exists a good correlation between different biochemical markers, suggesting the fact that they investigate similar process. While the role of biochemical markers are studied and many researchers have opined that they are better than liver biopsy, currently liver biopsy still enjoys the first line investigation method for diagnosis and staging of liver fibrosis. Imaging studies and genetic studies are also considered useful, but in research stage. Excessive accumulation of various extrace llular matrix proteins like collagen is known as liver fibrosis. The condition arises because of chronic damage to the liver due to one or more causes like chronic hepatitis C infection, non-alcoholic steatohepatitis and alcohol abuse. It has the potential to progress to advanced liver conditions like liver failure, cirrhosis and portal hypertension, requiring liver transplantation (Bataller and Brenner, 2005). As of now, there is no standard treatment for liver fibrosis. Though some treatments have been found effective among rodents, they have not been practical to apply on humans because of the difficulties associated with performing serial biopsies to evaluate and ascertain the changes associated with treatment accurately and also because of the fact that humans are much less sensitive towards antifibrotic treatments when compared to rodents (Bataller and Brenner, 2005). Currently, the most effective treatment for liver biopsy appears to be removal of the offending agent and the only curative approach for those with cirrhosis and complications is liver transplantation which improves not only the quality of life, but also the survival (Bataller and Brenner, 2005). Management of liver fibrosis is mainly based on the accuracy of the degree of liver fibrosis. Those with chronic liver disease need to be frequently evaluated for detection of liver fibrosis in early stages. Traditionally, liver biopsy was considered to be the "gold standard" test for ascertaining and evaluation liver biopsy. However, this test is fraught with several limitations and risks because of the invasive nature of the procedure. Recent investigations like biochemical tests, liver magnetic resonance imaging and genetic evaluation are non-invasive and overcome the disadvantages of liver biopsy. However, some experts continue to employ liver biopsy for evaluation of liver biopsy arguing that it is a more accurate assessment strategy. In this research article, both traditional and modern metho ds of liver fibrosis evaluation will be compared and discussed through review of suitable literature. A brief overview of the pathogenesis of the disease will be

Lit review Essay Example | Topics and Well Written Essays - 2500 words

Lit review - Essay Example 000 as command center for the acquisition of equipment and supplies of all the armed services – RAF, Navy and ground forces – representing a major restructuring in defense culture and processes. This major command was created precisely to improve logistics acquisition by moving from a functional to a project-based organizational structure. Under the DLO, a total of 144 Integrated Project Teams were organized, one for each type of military equipment and supplies. Each IPT has its own set of assembly staff, logisticians, engineers, contractors and financial team, operating much like a business organization. Lysons, K. and Farrington, B. (2006)note that the Purchasing and Supply Chain Management (PSCM) concept was started in February 2001 to reduce costs as soon as possible and improve overall performance by addressing the following concerns: supplies concerns consumable items or those equipment components that can be easily repaired. Even in the US Air Force, the difficulty of finding cheap consumable parts is blamed for 40 per cent of aircraft downtime. To handle this specific problem, the IPTs created the positions of supply Range Managers (RMs) under its wing to exclusively attend to the problem of high procurement costs. In effect, the Range Managers were handed the decision-making task of finding the methods of procurement and selection of suppliers that would translate into cost-efficient defense spending. As decision-makers, the Range Managers are expected to formulate measures that would cut costs and make their organization more efficient and viable. But the task of making decisions for an organization is not as easy as it seems. Any organization is a technical instrument for mobilizing human energies and directing them toward set goals. Janczak, 2005. The main function of the organization is decision-making which entails planning, evaluating and implementing. These decision-making processes may be disrupted by petty politics and